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Genetics versus Lifestyle - Which has a greater impact on your health?

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Genetics vs Lifestyle - Which has a greater impact on your health?

Our genes can influence health outcomes to a certain degree. But how much of our health is pre-determined by our genetics as compared to the lifestyle we lead?

A recent study examined the effects of genetic risk and lifestyle behaviours. The findings revealed a significant influence of lifestyle choices on health outcomes.

Genetic risk showed a 21% increased risk of a decreased lifespan

An unfavourable lifestyle showed a 78% increased risk

Even with a genetic risk, you can reduce it by up to 62% with a healthy lifestyle

The combination of lifestyle factors that was shown to have the most benefit include:
  • never smoking
  • regular physical activity
  • sufficient sleep
  • healthy diet

This is very consistent with the concept of Lifestyle Medicine.

What is Lifestyle Medicine?

The past few decades have seen a considerable rise globally in the rates of chronic diseases, such as type 2 diabetes, high blood pressure, obesity and certain cancers.  However, up to 80% of all chronic diseases are preventable through adoption of a healthy lifestyle. 

Lifestyle medicine is a scientifically proven, evidence-based approach that incorporates six pillars to form the basis of treating the whole individual.  The pillars include healthy eating, physical activity participation, adequate sleep, avoidance of risky substances, positive social connections and stress resilience.  Applying the six pillars of lifestyle medicine, is a powerful intervention in the prevention, management and even reversal of chronic diseases.

The six pillars of lifestyle medicine

Nutrition

Latest scientific research supports the consumption of a predominantly whole-food, plant-based diet, comprising of a variety of fruits, vegetables, legumes, wholegrains, nuts and seeds.  This pattern of eating has been shown to reduce the risk of chronic diseases, including type 2 diabetes, hypertension, heart disease and certain cancers. 

Physical Activity

For adults, physical activity guidelines recommend engaging in at least 150 minutes of moderate-intensity exercise each week. This can include activities such as brisk walking, swimming, cycling, dancing, or participating in sports. Additionally, it's advised to incorporate at least two strength training sessions per week that target all major muscle groups.

Regular physical activity plays a crucial role in both preventing and managing chronic diseases. It significantly improves mood, reduces the risk of depression and anxiety, and enhances overall well-being.

Sleep

Decreased or irregular sleep can result in increased appetite, insulin resistance, reduced attention span, low mood, and decreased emotional regulation. Adults should aim for 7 to 9 hours of sleep each night and maintain a consistent sleep and wake schedule throughout the week, including weekends.

Avoidance of Risky Substances

Tobacco use and increased alcohol consumption are common behavioural risk factors linked to both physical and mental health conditions, and are key contributors to preventable deaths. Tobacco use includes cigarettes, shishas, cigars, roll-your-own tobacco and e-cigarettes, all of which are harmful with no safe level of exposure.  Smoking cessation support can be obtained through your health care provider.

Similarly, increased alcohol consumption is associated with significant risks, accounting for at least 31 health conditions.  The British Heart Foundation recommend limiting alcohol to 14 units per week, spread through the week and having alcohol free days.  One unit of alcohol is roughly equivalent to either half a pint of regular beer, half a small glass of wine or a single measure of spirits.  However, the World Health Organisation have stated:when it comes to alcohol consumption, there is no safe amount that does not affect health.”  Therefore, minimising alcohol consumption well below the recommended limits is beneficial for everyone.

Stress Resilience

Although stress is often unavoidable, how we manage stress is crucial to the outcome of our physical and mental health.  Adopt stress management techniques to ensure optimal physical and mental health.  Spend time in nature, practice mindfulness through activities like yoga and breathing exercises, keep a gratitude journal, connect with others, and make time for the hobbies you enjoy.

Social connections

Humans have evolved with a fundamental need for social interactions, which strengthens our sense of belonging and acceptance.  The impact of loneliness and social isolation on health is comparable to other well established risk factors such as smoking and physical inactivity. 

Enhance social connections by scheduling time to connect with family, friends and neighbours.  Consider engaging in community-based activities, such as faith-based organisations, take up a class to learn something new or restart an old hobby.  These activities provide opportunities to connect with others who share your interests, fostering new relationships and strengthening social bonds.

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Making Lifestyle Changes

The key is to focus on making small, sustainable changes that can lead to significant long-term benefits. For instance, you may be more likely to stick with physical activity if it involves social interaction, like playing tennis with friends, rather than committing to a gym membership. Having an accountability partner when making lifestyle changes can also increase your success through providing support and motivation.

References :

  1. Bian Z, Wang L, Fan R, et al Genetic predisposition, modifiable lifestyles, and their joint effects on human lifespan: evidence from multiple cohort studies BMJ Evidence-Based Medicine 2024;29:255-263.
  2. https://lifestylemedicine.org/
  3. https://www.bhf.org.uk/informationsupport/support/healthy-living/healthy-eating/alcohol
  4. https://www.who.int/news-room/fact-sheets/detail/alcohol
  5. https://www.who.int/news-room/fact-sheets/detail/tobacco

Disclaimer: 

The content in this article is for general informational purpose and is not meant to replace or substitute for professional medical advice, diagnosis or treatment.  Always consult a qualified healthcare professional with any questions or concerns about your health.